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Fasting science, one process at a time

What happens when you stop eating is genuinely interesting, and most of it is well described. This section covers the physiology one process at a time: the fuel your body switches to, the signals that drive the switch, and how each claim is measured.

Every page here is drawn from peer-reviewed research, traced to a dated evidence packet, and kept separate from Burn's own stage labels.

Sourced from the literature

Claims come from peer-reviewed research, recorded in an evidence packet with its sources, search date, and review date.

Product and science kept apart

Burn's nine stages are product labels for elapsed time. Where a page mentions them, it says so plainly.

Reviewed and dated

Each page carries a review date, and corrections are published rather than quietly edited in.

Start here

Three pages that cover most of it

Read these three in order and the rest of this section will make sense.

FOUNDATION

How intermittent fasting works

The whole mechanism in one place: insulin falling, glycogen draining, fat taking over, and what that adds up to.

Read the explainer →

MEASURABLE

Ketosis and fasting

What ketones are, what a blood test actually tells you, and why the onset hour varies from person to person.

Read about ketosis →

MOST DEBATED

Autophagy and fasting

Cellular recycling, where the evidence comes from, and why measuring it takes a laboratory.

Read about autophagy →

The fuel switch

Follow it in order

Six pages, in the sequence your body works through them. Each one is a single process rather than a grand claim.

01

Fed versus fasted

Two states, and what separates them.

02

Glycogen depletion

The easy fuel, and how long it lasts.

03

Gluconeogenesis

Making glucose when none is coming in.

04

Lipolysis

Releasing stored fat into the bloodstream.

05

Fat oxidation

Burning it, and how the rate changes.

06

Metabolic switching

Moving between fuels, and what it costs.

Everything in this section

All seventeen pages

Fuel and metabolism

What your body runs on, and when it changes.

How intermittent fasting works Fed versus fasted Glycogen depletion Metabolic switching Gluconeogenesis Lipolysis Fat oxidation Fasting and metabolism

Ketones

The part of a fast you can actually measure.

Ketosis and fasting When does ketosis start? Blood ketones

Autophagy

Cellular recycling, and the limits of what is known.

Autophagy and fasting When does autophagy start? Can you measure autophagy?

Signals and hormones

The machinery that responds to going without food.

Insulin and fasting Blood glucose and fasting AMPK, mTOR and fasting

Looking for the hour by hour version?

The science pages cover one process each. If you want to know what is happening at a specific point in a fast, the stage pages walk through it in order.

Go to fasting stages →

How we source and correct

Our editorial standards set out where claims come from, who reviews them, and how corrections are published.

Read our editorial standards →

Burn names all nine stages as you reach them and tells you how firm the evidence behind each one is.

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